The central and peripheral circadian rhythms control nearly all cellular processes and immune regulatory mechanisms. The master clock, located at the suprachiasmatic nuclei (SCN) is entrained mainly by light dark cycle and is responsible for the majority of the biological rhythms. The peripheral tissues such as that in the gastrointestinal (GI) tract and the liver, however, possess self-sustaining circadian timers that can be regulated by other factors such as food. Circadian rhythm disruption can occur as the result of several conditions such as shift workers, social jet lag, or abnormal sleep and feeding patterns and can disturb the circadian homeostasis in the GI tract and liver, and cause metabolic and immune dysregulation, leading to a variety of pathologies.
The circadian rhythm in GI tract motor and secretory activities has been observed for decades. The role of circadian homeostasis in cell proliferation, immune homeostasis, gut permeability and microbial imbalance is being increasingly recognized. This symposium will provide scientists, post-doctoral fellows, fellows-in-training, clinicians, and clinician-scientists with a highly dynamic and interactive environment to discuss and learn about the impact that circadian rhythms may be having on a variety of digestive and alcohol related pathologies such as metabolism, gut inflammation, liver diseases, brain-gut pathways, and GI cancers.
The following topics will be covered in this symposium:
- Role of Circadian Rhythm in Digestive Diseases
- Role of Circadian Dysrhythmia in Gastrointestinal Diseases
- Role of Circadian Rhythms in Obesity, and Metabolic Syndrome
- Role of Circadian Dysrhythmia in alcoholic and non-alcoholic liver disease
- Role of Circadian Dysrhythmia in Brain-gut axis
- Role of Circadian Dysrhythmia in in Gastrointestinal Cancers
- Therapeutic Implications of Circadian Science in GI diseases
Provided by Rush University Medical Center, supported in part by NIH-NIDDK-NIAAA