GI Circadian Meeting

Program Schedule | Friday, May 6th

Time

Event

8:00a.m.-8:30a.m. Breakfast

Session 1 (8:30a.m.-9:55a.m.)

Time and Brain – Gut Axis

Moderator: Ali Keshavarzian, M.D.

8:30a.m.-8:50a.m. Eating Pattern and the Brain
Mark Mattson, Ph.D.
8:50a.m.-9:10a.m. Challenges in Measuring and Shifting the Central Circadian Clock
Helen Burgess, Ph.D.
9:10a.m.-9:20a.m. Role of Intestinal Microbiota Composition, Intestinal Inflammation and Gene Expression in PD: Impact of Circadian Rhythm Disruption
Robin M. Voigt, Ph.D.
9:20a.m.-9:30a.m. Alcohol Sensitivity and Mortality are Increased with Aging and Circadian Dysfunction
Aliza K. De Nobrega
9:30a.m.-9:45a.m. Panel Discussion

Session 2 (9:45a.m.-11:05a.m.)

Circadian Dysrhythmia in Gastrointestinal Cancer

Moderator: Paolo Sassone-Corsi, Ph.D.

9:45a.m.-10:05a.m. Circadian Disruption, Colonic Inflammation and Carcinogenesis
Khashayar Khazaie, Ph.D.
10:05a.m.-10:20a.m. Food Timing and Colon Carcinogenesis
Faraz Bishehsari, M.D./Ph.D.
10:05a.m.-10:20a.m. Tumor Macroenvironment Alters Circadian Metabolism
Selma Masri, Ph.D.
10:20a.m.-10:40a.m. Circadian Clocks, Epigenetics, and Gastrointestinal Cancers
Paolo Sassone-Corsi, Ph.D.
10:45a.m.-10:50a.m. Impact of Circadian Disruption and Subjective Sleep Complaint on Metastatic Colorectal Cancer Patients Outcomes
Pasquale F. Innominato
10:50a.m.-11:05a.m. Panel Discussion
11:05a.m.-11:30a.m. Coffee Break

Session 3 (11:30a.m.-1:00p.m.)

Therapeutic Implications: Where are We and Where Might We Go?

Moderator: Francis Levi, M.D.

11:30a.m.-11:50a.m. Clock-Targeting Pharmaceuticals for GI Cancer
Roman Kondratov, Ph.D.
11:50a.m.-12:10p.m. Chronotherapy and the Molecular Clock: Clinical Implication for GI Cancer
Francis Levi, M.D.
12:10p.m.-12:30p.m. Therapeutic Role of Melatonin in GI Diseases
Russel Reiter, Ph.D.
12:30p.m.-12:40p.m. Toward Determing in Vitro Chronopharmacology of the MTOR Inhibitor Everolimus in urine Hepatocarcinoma Cells
Kristin Abraham
12:40p.m.-12:55p.m. Panel Discussion
12:55p.m.-2:00p.m. Keynote Lunch (Four concurrent lunch sessions- select 1 session during registration process)

1. Moderators: Ali Keshavarzian, M.D. & Eugene Chang, M.D.
Session Theme: Why circadian rhythms should be incorporated in management strategies for GI diseases
Duration (with Discussion, Q&A): 1 hr
Moderators’ Affiliation: Rush University Medical Center, USA & University of Chicago, USA

2. Moderators: Fred W. Turek, Ph.D. & Carla Green, Ph.D.
Session Theme: Obesity, a circadian disease?
Duration (with Discussion, Q&A): 1 hr
Moderators’ Affiliation: Northwestern University, USA & UT Southwestern, USA

3. Moderators: Paolo Sassone-Corsi, Ph.D. & Khashayar Khazaie, Ph.D.
Session Theme: GI cancers and circadian: Future directions
Duration (with Discussion, Q&A): 1 hr
Moderators’ Affiliation: University of California, USA & Mayo clinic, USA

4. Moderators: Francis Levi, M.D. & Russel Reiter. PhD, Dr. Hellen Burgess PhD.
Session Theme: Development of Circadian-based therapies in GI diseases
Duration (with Discussion, Q&A): 1 hr
Moderators’ Affiliation: Cancer Chronotherapy Unit, Warwick Universit, UK ; Department of Cellular and Structural Biology, The University of Texas Health Science Center, USA & Rush University Medical Center, USA

2:00p.m.-2:15p.m. Conclusion and Remarks